HMGB1/CXCL12 heterocomplex activates CXCR4 to suppress the ability of Muller glia to become proliferating progenitor-like cells in the chick retina

We investigated how High Mobility Group Box 1 (HMGB1) signaling regulates glial reactivity and Muller glia-derived progenitor cell (MGPC) formation in the chick retina. HMGB1 released from stressed cells is known to form a heterocomplex with C-X-C chemokine ligand 12 (CXCL12) to activate C-X-C chemokine receptor 4 (CXCR4). HMGB1 is broadly expressed in retinal neurons and glia and is rapidly…

biorxiv.org ·1d ago

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