Functional Conservation Amid Extreme Divergence in Freshwater SAR11 Hypervariable Region 2

The Ca. Pelagibacterales order (SAR11) is a ubiquitous bacterioplankton in aquatic ecosystems. The genomes of SAR11 bacteria contain hypervariable region 2 (HVR2), the largest HVR with extreme diversity. Previous studies collectively indicated the enrichment of cell-surface modification genes on HVR2, which have been hypothesized to facilitate phage evasion. However, characterisation of HVR2 has…

biorxiv.org ·1d ago

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