Epigenetic Mechanisms Inhibit Smad7 and Contribute to Fibrosis in Crohn's Disease

Background & Aims: TGF-beta1 is a central regulator of profibrotic gene expression, extracellular matrix deposition, and the development of intestinal fibrosis in patients with fibrostenotic Crohns disease (CD). Unlike the increased expression of Smad7 in mucosal and lamina propria monocytes, where it impairs Treg function, mesenchymal cells from patients with fibrostenotic CD do not exhibit…

biorxiv.org ·1d ago

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