Donor-associated variation outweighs PMOS status in patient-derived iPSC transcriptomes: a genotyped, BMI-adjusted study of 14 lines
Abstract Background: Induced pluripotent stem cells (iPSCs) from patients have been little used to model polyendocrine metabolic ovarian syndrome (PMOS, formerly polycystic ovary syndrome, PCOS), and differences between unrelated donors can masquerade as disease effects. Earlier comparisons of three or four donors per group reported hundreds to thousands of differentially expressed genes. We…
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