Distinct Roles of ADP and Magnesium in the Structural Remodeling and Higher-Order Assembly of Peroxiredoxin 2

2-Cys peroxiredoxins (Prxs) undergo oligomeric transitions linked to peroxidase and chaperone activities, but the contributions of nucleotides and cations to lipid-dependent assembly remain unclear. We examined phosphatidylserine (PS)-induced Prx2 oligomers using biochemical assays and high-speed atomic force microscopy (HS-AFM). Both wild-type (WT) and P44A/S76A mutant (MT) Prx2 formed…

biorxiv.org ·1d ago

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