Disentangled generative modeling of single-cell perturbation responses across dynamic cellular states
Single-cell perturbation studies are increasingly conducted across complex, multi-condition biolog-ical systems, offering a powerful lens into how interventions reshape cell states and molecular pro-grams. However, standard computational models compress single-cell profiles into unified repre-sentations where treatment effects are obscured by cell division, lineage progression, donor varia-tion,…
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