Computational model of developmental self-assembly of a cortical microcircuit
Cortical microcircuits emerge from local developmental interactions, yet large-scale computational models typically prescribe connectivity rather than explain its formation. Here we use BioDynaMo to simulate the self-assembly of ~70,000 cortical neurons from 1,200 progenitors in 3D physical space through migration, neurite growth and contact-based synapse formation. With one calibrated filling…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
