Chemotherapy for breast cancer linked to accelerated biological aging
Chemotherapy helps many women survive breast cancer, but new research suggests that chemotherapy may also accelerate biological aging beyond chronological age and increase the risk of earlier death from other causes. The findings point to a need to explore whether interventions to slow or reverse biological aging could improve long-term health for breast cancer survivors.
New research suggests chemotherapy may accelerate biological aging and reduce healthy life years for breast cancer survivors. Georgetown University's Lombardi Comprehensive Cancer Center conducted a study estimating the balance between curing breast cancer and possible acceleration of biological aging through simulation modeling.
Jeanne Mandelblatt, director of the Institute for Cancer and Aging Research, notes that chemotherapy-induced molecular damage can lead to earlier onset of aging diseases and conditions. The study, published in JAMA Open Network, found that breast cancer survivors receiving the most cytotoxic anthracycline regimens may lose 9.4 remaining life years, primarily due to earlier onset of aging-related diseases.
The research highlights the need to explore interventions to slow or reverse biological aging to improve long-term health for breast cancer survivors.
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