Miami vs. Notre Dame prediction, odds, pick for college football Week 10

The Miami Hurricanes are set to face the Notre Dame Fighting Irish in a highly anticipated college football game on Saturday night at 7:30 p.m. ET. Miami enters the matchup as the No. 1 team, sitting at an impressive 8-0 record, while Notre Dame stands at 7-1. The Hurricanes have dominated their first four games with scores of 33 points or more, reaching a high of 77 points, and have also won their last five games, including a blowout victory over Stanford.

However, Notre Dame's perfect start to the season came to an end with a 28-24 upset loss to BYU. The teams have met 28 times previously, with Notre Dame holding a slight edge in victories with 17 compared to Miami's nine. Head-to-head, the Hurricanes have triumphed in the most recent meeting in 2025, winning 27-24. The betting odds favor Notre Dame with a -7 spread and a -110 line, while Miami is listed at +7 with the same odds.

The game's key matchups include Miami's potent offense led by Darian Mensah, who has thrown for 2,425 yards, 25 touchdowns, and one interception, and his supporting cast of Mark Fletcher Jr., Javian Mallory, and Cooper Barkate. Notre Dame's offense features CJ Carr, who has completed 148 of 222 passes for 1,849 yards and 18 touchdowns, and the receiving duo of Nolan James Jr. and Jonaz Walton.

On defense, Miami must find ways to disrupt Notre Dame's attack without their leading receiver Malachi Toney, while Notre Dame will rely on their top four defenders - Drayk Bowen, Luke Talich, Leonard Moore, and Boubacar Traore - to prevent Miami from scoring. With both teams vying for a crucial position in the CFP bracket, this matchup is poised to be a game of the year candidate.

The prediction is Miami +7 (-110) and over 54 (-115), suggesting a solid victory for the Hurricanes and a high-scoring game.