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Where DNA Copying Fails Can Decide How Cancer Cells Respond to PARP Inhibitors

NYU Grossman School of Medicine researchers found that DNA-copying problems at a small set of chromosome sites can determine how cancer cells respond to PARP inhibitors, pointing to possible…

  • ESCO2 protein linked to PARP inhibitor sensitivity in cancer cells
  • G-quadruplexes accumulate at specific replication sites in ESCO2-depleted cells
  • PARP inhibitors disrupt protective response, increasing DNA damage at centromeres

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