Harmonizing scientific terms and concepts in early celiac disease
With increasing research on the interplay between genetics and environmental risk factors in the early stages of celiac disease, the need to harmonize scientific terms and concepts in this field has increased. In an effort led by researchers at Karolinska Institutet and the Mayo Clinic, 22 scientists from seven countries have published a review on the stages of early celiac disease. The paper is…
The rising incidence of celiac disease (CeD) worldwide has prompted researchers to harmonize scientific terms and concepts related to the early stages of the condition. Led by Karolinska Institutet and the Mayo Clinic, a team of 22 scientists from seven countries have published a review in Gut detailing their efforts to establish consistent terminology.
Celiac disease is an immune-mediated disorder that causes small intestinal enteropathy and currently affects approximately 1% of the global population. To tackle this, the International Society for the Study of Coeliac Disease (ISSCD) established a task force, known as the Before Coeliac Disease (B4CeD) task force, to define key concepts about early CeD development.
The B4CeD task force reviewed a substantial number of scientific publications - 2,623 in total, with 438 read in full - to harmonize essential terms and concepts. The objective was to facilitate better research and clinical practice for individuals at the early development stage of CeD, according to first author Jonas F. Ludvigsson, a professor and pediatrician at Karolinska Institutet and Örebro University Hospital.
Ludvigsson emphasized that consistent use of scientific terms and concepts will help compare research findings, increase translatability into clinical practice, and improve clinical guidelines. The review of published literature aims to enhance comparability of research findings and ensure their effective translation into clinical practice and guidelines.
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