FUSION PORE CLOSURE DETERMINES SUBQUANTAL KISS-AND-RUN SEROTONIN RELEASE FROM FULLY LOADED DENSE-CORE VESICLES
During kiss-and-run exocytosis, a transient fusion pore opens, releases part of the vesicular quantum, and closes without full fusion. This report investigates two questions: first, whether dense-core vesicles undergoing kiss-and-run contain the same number of molecules as those undergoing full fusion; second, whether subquantal release results from pore closure or vesicle depletion. We analyzed…
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