The Pseudomonas protegens PBL3 secretome exerts antimicrobial activity against Burkholderia glumae by disrupting cell envelope homeostasis and impairing bacterial replication
The effectiveness of antimicrobials used to manage bacterial infections is increasingly threatened by the emergence of antimicrobial resistance. Many conventional antimicrobials act on a single defined target that pathogens can circumvent through target modification or pathway adaptation. In contrast, antimicrobials that disrupt multiple cellular processes may impose greater fitness costs and…
Bacterial infections pose a growing threat due to the rise of antimicrobial resistance. Many traditional antimicrobials target specific bacterial pathways, but pathogens can adapt by modifying targets or pathways. To combat this, researchers are exploring antimicrobials that target multiple cellular processes, as these are less likely to be resisted.
A study on the bacterium Pseudomonas protegens PBL3 found that it produces a secretome containing molecules that can kill several plant and human pathogens. However, the exact mechanism was unclear. The researchers used the plant pathogen Burkholderia glumae to study the impact of the P. protegens PBL3 secretome. They discovered that the secretome causes significant damage to the bacterial cell envelope, leading to cell death and inhibiting bacterial replication.
Further investigation revealed that the secretome disrupts a wide range of processes related to cell-envelope formation, maintenance, and bacterial growth. These findings suggest that the P. protegens PBL3 secretome functions as a multi-target antimicrobial, offering potential for developing new treatments to combat bacterial infections in agriculture and medicine.
Written by urgent.news from bioRxiv's reporting — not their text. Machine-written — may contain errors; check the original before relying on it.
This story
This is one outlet's version. Read the fullest account.
