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Clinical-Anchored Incremental Survival Learning: A Stability-Constrained Framework for Molecularly Enhanced Survival Prediction in Lung Adenocarcinoma

Accurate survival prediction in lung adenocarcinoma (LUAD) remains challenging because high-dimensional molecular data can introduce overfitting and unstable feature selection. We developed Clinical-Anchored Incremental Survival Learning (CAISL), a framework that integrates a sparse molecular risk correction with a clinical baseline to improve prognostic discrimination while constraining model…

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