Transferrin receptor binding valency determines the circulating half-life and weight-loss efficacy of Fc-FGF21 in TfR-humanized mice
Fibroblast growth factor 21 (FGF21) is a promising metabolic hormone with potent anti-obesity effects. It acts in both the central nervous system and peripheral tissues to exert its metabolic benefits. Because its receptors are expressed at low levels in the brain, we hypothesized that enhanced transport across the blood-brain barrier (BBB) would improve its efficacy. To achieve this, FGF21 was…
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