Suspended Vials Help Optimize Continuous Freeze-Drying
Researchers have developed a process with suspended vials accompanied by a digital twin for optimized continuous and autonomous freeze-drying. It offers more uniform and better-quality products, and higher yields. The post Suspended Vials Help Optimize Continuous Freeze-Drying appeared first on GEN - Genetic Engineering and Biotechnology News .
U.S. researchers from the Massachusetts Institute of Technology (MIT) have discovered a method to optimize continuous freeze-drying by suspending vials on wires during the process called lyophilization. This technique leads to a more uniform drying process, resulting in a more consistent product. Dr. Prakitr Srisuma, a former researcher at MIT’s Argonne National Laboratory, explains that this suspension provides the benefits of continuous processing, such as increased production capacity and enhanced quality control.
Unlike traditional drying methods where vials can be moved around, causing disturbance, suspended vials maintain a stable position, ensuring consistent exposure to drying conditions and minimizing friction-related issues. The team has also created a digital twin of the continuous lyophilizer, which they will use to develop advanced predictive control and optimization strategies. Moving forward, they may explore using microwave lyophilization as part of their research efforts.
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