Perturbation-induced gene programs map the hidden regulatory architecture of complex diseases
Steady-state molecular profiles incompletely capture the regulatory programs through which genetic variation influences complex disease, particularly programs that emerge only when cells are perturbed. Here, we introduce Perturbscape, a computational framework that learns multiscale gene programs for individual perturbations in a CRISPR Perturb-seq screen using linear and nonlinear contrastive…
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