Our college football picks for Louisville-Georgia Tech, Kentucky-Tennessee, more

This week's college football picks feature five road games for commonwealth teams. Kentucky will travel to Tennessee, while Louisville plays Georgia Tech and Western Kentucky faces Middle Tennessee. The other two matchups are Texas against Missouri and Miami at Notre Dame. Predictions are made based on the latest US LBM Coaches Poll, with rankings indicating straight-up winners and losers. All times are in ET, and betting odds are provided as per DraftKings as of Tuesday, November 3.

The Louisville Cardinals are on a three-game winning streak after three early losses, and they are favored to defeat Georgia Tech, who have struggled defensively. Kentucky’s quarterback situation remains uncertain, with George MacIntyre or Faizon Brandon potentially taking the field. Tennessee, currently 6-2 overall and 3-2 in conference play, is favored against Kentucky, who must maintain their College Football Playoff chances.

Middle Tennessee has been dominant in the U.S. Route 231 rivalry, holding a 39-35-1 edge over Western Kentucky over the past 75 years. The Hilltoppers are on a seven-game winning streak, and they are favored against WKU. Texas, playing their first significant road game in over a month, is favored against Missouri, who have the best turnover margin in the SEC at +8.

Miami, still undefeated, faces Notre Dame, a potential game changer if the Fighting Irish upset Miami.