Longer estrogen exposure linked to better brain vessel health in older women
Women who had a longer reproductive period and had used or are using hormone replacement therapy showed fewer signs of damage to the small blood vessels in the brain later in life. This is shown by a study led by researchers at Karolinska Institutet, published in the journal Neurology.
A research study conducted by scientists at Karolinska Institutet and published in Neurology reveals that women who experienced a longer reproductive period and used hormone replacement therapy had better brain vessel health in their later years. The study analyzed 352 women aged 70 without cognitive impairments, examining their brain scans taken at age 70 and five years later.
Data on the age of first menstruation, menopause onset, and previous contraceptive pill and hormone replacement therapy use were also considered. The findings show a correlation between longer reproductive periods and lower small-vessel disease burden, along with a more favorable microstructure in the brain's white matter. Women who utilized both the contraceptive pill during their reproductive years and hormone replacement therapy during menopause exhibited the most advantageous vascular brain health profile.
Researchers emphasize that hormonal exposures throughout a woman's life may influence cerebrovascular health in later life, highlighting the potential importance of brain blood vessels in the relationship between estrogen and brain aging. However, the study's limitations include self-reported hormone use data and observational design, preventing the establishment of cause-and-effect relationships or recommending hormone therapy for preventive purposes.
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