Facilitating the identification of cryo-EM hit matter in drug discovery with Astex-Faro
Cryogenic electron microscopy (cryo-EM) is emerging as a tool for large-scale ligand screening and fragment-based drug discovery, generating extensive collections of reconstructions. At the same time, the systematic inspection of local density variations remains challenging, particularly when identifying weak or partially occupied features. Here, we present Astex-Faro, a statistical framework…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
