Conserved synaptic modifications by humanized tau through diverse isoform- and mutation-specific intracellular interactions
Mutations in the microtubule-binding protein tau are considered causal for a diverse group of neurodegenerative diseases collectively referred to as primary tauopathies. Specific tauopathies are associated with different mutations, distinct tau isoforms, manifest in unique cellular and circuit-wide patterns of degeneration, and present with specific clinical symptoms and trajectories. The…
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