Computational Analysis of Antioxidant Effects on Stress Response Mechanisms in Candida albicans

Candida albicans was used as a eukaryotic model to study aging and oxidative stress response pathways focused on NAD dependent deacetylases, Sir2 and SIRT3. A significant gene expression regulation of both Sir2 and SIRT3 was observed under sublethal hydrogen peroxide treatment towards their association with stress adaptation. Natural ligands known for antioxidant properties were docked against…

biorxiv.org ·12h ago

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