CloneVI: A deep generative model for deciphering the relationships between cell state and mitochondrial genotype
Cellular diversity arises from both genetic lineages and non-genetic regulation of cell states, and knowing which cell states are tied to lineages is central to understanding how clones shape disease. Single-cell multi-omics technologies measure mitochondrial DNA mutations together with gene expression or chromatin accessibility in the same cells, but clones are usually inferred from mutations…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
