Cellular composition and the interpretation of candidate RNA readouts of trogocytosis in colorectal cancer
Background: RNA measurements of genes associated with trogocytosis may reflect cellular composition rather than contact-dependent membrane acquisition. We evaluated an eight-gene candidate module in colorectal cancer (CRC) using expression- and lineage-matched random modules, independent compartment analysis and patient-level inference. A separate rare-transcript definition and cancer-model…
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