Cascaded Dual-Targeting (WTW/TAT) Liposomes Delivery DOX for Precision Glioblastoma Treatment

Glioblastoma (GBM) remains difficult to treat because the blood-brain barrier (BBB) and blood-tumor barrier (BTB) severely limit drug transport into tumor tissue. To address these delivery constraints, we developed a dual-targeted liposomal nanoplatform (WT-LIP) that integrates a WTW dual-targeting peptide to promote receptor-mediated BBB transcytosis and specificity to GBM and a TAT peptide to…

biorxiv.org ·12h ago

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