Building Custom DNA without Bacterial Constraints
Moving high-fidelity DNA assembly from the production queue to the lab bench and the science can start sooner. The post Building Custom DNA without Bacterial Constraints appeared first on GEN - Genetic Engineering and Biotechnology News .
Building custom DNA sequences has traditionally involved using bacteria as hosts, a process that is slow, requires biosafety infrastructure, and can fail on complex sequences. Ribbon Bio has developed a technology that removes the need for bacterial hosts, eliminating issues like endotoxins and residual genomic DNA. Their cell-free assembly technology allows for faster and more reliable construction of complex DNA molecules.
Ribbon Bio's MiroMine kit enables users to build DNA molecules up to 7 kilobases in length using standard lab equipment. The kit's proprietary software identifies potential issues in target sequences and designs oligo pools to avoid them. This results in higher success rates and faster turnaround times for DNA synthesis. Flock Bio, another company, has already adopted Ribbon Bio's technology for building custom DNA libraries, demonstrating its potential for accelerating research in areas such as antibody discovery and binder design.
By eliminating the need for bacterial hosts, Ribbon Bio's approach reduces contamination risks, improves endotoxin levels, and shortens production cycles, making it an attractive option for scientists seeking faster and more efficient DNA assembly.
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