Bicarbonate-free pH neutralization resensitizes ovarian cancer to chemotherapy and is tracked by 3T CEST MRI
Ovarian tumors that initially respond to platinum-taxane chemotherapy often relapse as chemoresistant disease. The acidic tumor microenvironment is a well-known but under-exploited driver of this resistance, and neutralization strategies such as oral bicarbonate have not translated. Here we show that inhibiting specific tumor pH regulators at noncytotoxic doses relieves acidosis and restores…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
