ssGSEA3.0: Feature-Level Bootstrap Resampling for Robust Assessment of Statistical Significance
Motivation Single-sample Gene/Post-Translational Modification Set Enrichment Analysis (ssGSEA/PTM-SEA) methods assess pathway or signature activity per sample using permutation-based significance testing. ssGSEA2.0's weighted scoring (ssGSEA2.0-orig) uses a correlation-vector reordering that inflates false positives at nonzero weight; directly fixing this (ssGSEA2.0-fixed) restores…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
