Cigarette smoke extract and palmitic acid exposed patient-derived iPS- RPE cells as a model for AMD
Purpose: Age-related macular degeneration (AMD) is a multifactorial disease in which dysfunction and loss of retinal pigment epithelial (RPE) cells contribute to disease progression. Besides genetics, cigarette smoking and high fat diet are important environmental and metabolic risk factors for AMD and are associated with RPE dysfunction. However, the effects of combined environmental and…
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