Bispecific VSV-G Engagers: A Platform for Cell-Type-Specific Delivery of Viral Vectors
VSV-G-pseudotyped lentiviral vectors (LVVs) enable highly efficient ex vivo gene delivery through the broadly expressed LDL receptor (LDLR) but lack the cell-type specificity required for in vivo applications. To provide cell-type specificity, we developed reversible engagers consisting of a cell-specific ligand or antibody fused to the ~40-amino-acid VSV-G-binding domains of LDLR. Following…
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