Biosensor-guided genome-wide CRISPR screens enable cis,cis-muconic acid overproduction in yeast
Classical pathway metabolic engineering relies on enhancing strain productivity through the introduction of rationally identified genetic perturbations, which while useful, are time-consuming and miss unintuitive targets. Genome-wide CRISPR screens offer an alternative by efficiently sampling genomes, enabling the engineering of novel phenotypes, and are further enhanced when combined with…
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