ANABOLIC FAILURE, NOT CATABOLIC ACTIVATION, UNDERLIES GLYCOGEN DEPLETION IN CERVICAL CARCINOGENESIS: A MULTI-COHORT TRANSCRIPTOMIC ANALYSIS
Abstract Background. Cervical epithelium loses its glycogen as disease grade rises, an observation old enough to underpin iodine-based visual screening, but which arm of glycogen metabolism accounts for the loss has not been established. The expectation from cancer metabolism is catabolic: that stored glycogen is mobilized and glycolysis activated. Methods. We analyzed 238 specimens from four…
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