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Age-related biological dysregulation quantified using metabolomics is composed of distinct subsystems with synergistic associations to health outcomes: An analysis of the Canadian Longitudinal Study on Aging

Resilience is a fundamental component of healthy aging, whereby an organism can efficiently respond to external stressors and return to a resting biological and physiological state, known as homeostasis. This capacity declines with age in a heterogenous manner and is aggravated by biological dysregulation, a detrimental state broadly associated with health risk factors and poor outcomes. However,…

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