A respiratory microdomain links ubiquinone biosynthesis to succinate dehydrogenase in an apicomplexan mitochondrion lacking Complex I
Mitochondrial complex I (CI) is a major entry point for NADH-derived electrons and an important site of redox regulation in most eukaryotes. However, apicomplexan parasites, including Toxoplasma gondii, lack CI, raising a fundamental question of how mitochondrial respiration is organized in these parasites. Here, we identify a parasite-specific mitochondrial microdomain that physically and…
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