A compact three-way junction oligonucleotide probe for widefield and super-resolution imaging of RNAs and proteins
Molecular imaging of RNAs and proteins requires methods that preserve nanoscale organization while enabling large-scale tissue analysis. However, weak or low-abundance targets often need signal amplification, which can increase labeling size, background, or signal spread and compromise super-resolution imaging. Here, we report a compact three-way junction (3WJ) oligonucleotide probe platform for…
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