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Structure-activity relationship study in soil identifies an effective broad-spectrum inhibitor of archaeal nitrification

Ammonia-oxidizing archaea (AOA) can contribute substantially to nitrification in agricultural soils, yet the portfolio of AOA-targeting nitrification inhibitors (NIs) with demonstrated efficacy under soil conditions remains limited. Moreover, the performance of candidate inhibitors in soil is often difficult to predict from pure-culture assays because their activity is strongly influenced by…

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