Quantitative spatial connectomics of liver reveals a partially exposed sympathetic network that integrates multiple cell types across the portal tract
Peripheral tissues are innervated by sparse axonal networks that regulate homeostasis, regeneration and disease, yet their three-dimensional architecture and cellular targets remain largely unknown. Here, we present an EM workflow for quantitative 3D spatial connectomics to define these networks. We identify the mouse liver connectome as a meshwork, rather than a tree-like structure, of mainly…
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