Protein co-scientist aided simulations of the structural and functional impact of O-GlcNAc Transferase TPR domain deletions and amino acid substitutions associated with X-Linked Intellectual Disability
O-GlcNAc transferase (OGT) is an essential glycosyltransferase that regulates cellular processes through the addition of O-linked {beta}-N-acetyglucosamine (O-GlcNAc) to target proteins. Substrate recognition and protein-protein interactions are mediated by the tetratricopeptide repeat (TPR) domain, yet the contributions of individual TPR repeats to structural stability and function remain poorly…
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