Prevention of Klebsiella pneumoniae antibiotic resistance plasmid dissemination by prophylactic or simultaneous CRISPR-Cas9 treatment.
Antimicrobial resistance (AMR) is one of the most prevailing challenges of the 21st century, driven in part by pathogens such as Klebsiella pneumoniae which frequently disseminate plasmids carrying AMR genes within and across species. Mobile CRISPR-Cas9 tools can limit the spread of AMR plasmids through selective targeting but suffer efficacy issues when faced with ecological realism. Here, we…
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