Pregnancy History and Loss of Normal PSEN2 Function Impact Female Late-Life Cognitive Processing, Inhibitory Signaling, and Gliosis
Background. Alzheimer's disease (AD) is well-documented to be more progressive in affected females. It is thus critical to define how female-specific life experiences interact with AD-related risk factors to impact disease trajectory and functional burden. For example, pregnancy exerts dramatic influences on the maternal immune system, behavior, and neuroplasticity, specifically in hippocampal…
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