Mechanoadaptive focal adhesion-actomyosin coupling organizes diverse modes across ECM stiffness
Focal adhesions mechanically couple the actomyosin cytoskeleton to the extracellular matrix (ECM), contributing to mechanosensing and mechanical homeostasis. They span diverse states in response to the mechanical environment, from nascent adhesions and focal complexes to mature and supermature adhesions, undergoing dynamic remodeling. However, how ECM-dependent force generation and internal…
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