Mapping chromothripsis across human cancer cell lines reveals genome evolution and therapeutic vulnerabilities
Chromothripsis is a catastrophic chromosomal rearrangement found in ~40% of primary tumors, yet its landscape in cancer cell lines (CCLs) remains uncharacterized. To address this gap, we developed a pipeline to detect chromothripsis-like events from copy-number data alone, and mapped their occurrence across 1,646 human CCLs. Chromothripsis patterns were broadly conserved between primary tumors…
We haven't written up this one. bioRxiv has the full story — the link below goes straight to it.
