Laminin-Derived Peptides Bind Neuropilin-1 at the VEGF-A165 Binding Pocket
Neuropilin-1 (NRP-1) is associated with glioblastoma progression and contains a b1-domain pocket that binds the C-terminal region of VEGF-A165. Whether laminin-derived peptide fragments can associate with this site is unknown. AlphaFold 3 complex prediction followed by 15 s of all-atom production molecular dynamics simulation, trajectory-based pocket occupancy and interaction analyses, and FoldX…
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