KIF1A-driven entry of degradative lysosomes into the axon is developmentally regulated by the microtubule environment at the axon initial segment
Neuronal function requires precise transport of lysosomal vesicles along highly polarized processes, yet how this trafficking is spatially and developmentally regulated remains poorly understood. Here, we show that the neuronally enriched kinesin-3 motor KIF1A is required for dendritic and axonal localization of lysosomal vesicles in both immature and mature rat hippocampal neurons. Remarkably,…
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