Evolutionary tuning of complexin-synaptotagmin fusion clamp governs regulated neurotransmitter release
Synaptic vesicles must be held in a fusion-ready but restrained state until calcium influx triggers release. Synaptotagmin-1 (Syt1) and Complexin (CPX) both contribute to this fusion clamp, yet removing either protein produces opposite effects in different species. Whether this reflects genuine divergence in their molecular roles, or species-specific tuning of a conserved mechanism, has remained…
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