CNVSIM: an interpretable copy-number reference atlas for cancer subtyping
Background: Genome-wide copy-number variation (CNV) profiles provide a structural representation of cancer genomes, but interpreting new profiles within a reusable reference remains challenging. Results: We developed CNVSIM, which organizes CNV profiles into cancer root-specific reference spaces and defines reference subtypes annotated with chromosome-scale and gene-level signatures. Applied to…
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