An interferon-like off-switch in invertebrates: Vago4 downregulates Domeless to restrain JAK/STAT signaling
Whether invertebrates possess a functional interferon (IFN)-like system remains controversial, as canonical IFN ligands and their receptors are absent from invertebrate genomes. Although Vago proteins in Drosophila and shrimp are compelling functional analogs of IFN, direct evidence for a canonical cytokine-receptor axis and, importantly, for how such signaling is restrained to prevent excessive…
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