Achilles Heel: Type VII Toxin/Antitoxin System Hha/TomB Facilitates Phage Infection by Regulating Cryptic Prophage Lytic Genes
Toxin/antitoxin systems (TAs) are stress-response loci most-closely linked to stabilizing mobile genetic elements such as plasmids and inhibiting phage infection. In contrast to the phage inhibition paradigm, here we demonstrate that the type VII TA system, Hha/TomB, facilitates rather than inhibits Escherichia coli infection with 12 BASEL lytic phages (seven Tequatrovirus phages and five…
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