Tumour architecture profoundly influences cancer cell behaviour, yet functional genomic studies predominantly rely on two-dimensional (2D) cultures. Here, we performed parallel chromosome 1q focused CRISPR screens in matched 2D monolayers and three-dimensional (3D) spheroid cultures of luminal breast cancer cells, which revealed ARNT as a prominent architecture-dependent fitness regulator. ARNT…
Two-time Olympic gold medalist snowboarder Chloe Kim discusses how her recent diagnosis with attention-deficit hyperactivity disorder took a while and her ADHD treatment
Medical experts have advised women to prioritise their health and well-being by paying attention to their bodies and adopting healthy lifestyles to reduce Read More…
