Structural clustering across the tree of life reveals candidate Asgard-eukaryote homologs and a shared expansion of solenoids
Asgard archaea are the closest known prokaryotic relatives of eukaryotes, and their genomes encode many eukaryotic signature proteins (ESPs), homologs of proteins associated with eukaryotic cellular complexity. Because deep divergence limits sequence-based homology detection, structure-based searches are increasingly used to expand the ESP repertoire, but they start from individual Asgard…
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